Scope note: The AI & digital-health interventions shown here are illustrative “low-hanging fruit” — a small, high-feasibility/high-impact sample chosen to demonstrate planning-grade ROI. They are not an exhaustive or prescriptive list; many other interventions may apply.
Return on Investment - AI & Digital Health Interventions
Evidence-based ROI estimates for Isabella County, Michigan · Based on peer-reviewed meta-analyses · Soshnikov · 2026
Societal perspective includes healthcare costs, lost productivity, and criminal justice savings. Adjust reach sliders on each intervention below.
$2.58
Return per $1 invested (portfolio)
▲ Net benefit per year
$6.1M
Total annual investment required
All 6 programs combined
$15.7M
Estimated annual savings
5-yr net benefit: $48M
~254
Estimated DALYs averted/year
~1.7% of primary 15,430 burden
Methodology (June 2026 v5.0 update). ROI ratios are recalculated from Cochrane and peer-reviewed meta-analyses (Reilly 2024 for MH; Perry 2025 for MAT; Whittaker 2019 for tobacco; Agarwal 2025 for BP; Freeman 2021 for cancer screening; Jiang 2026 for diabetes). Formula: DALYs averted = target DALYs × programme reach × meta-analysis effect fraction; savings = DALYs averted × $62,000 (Michigan human capital rate, GDP per capita 2024). ROI = savings ÷ annualised investment. Estimates apply to Isabella County population subgroups derived from CDC PLACES 2024; SUD and CVD prevalence are derived, and several mortality inputs are rural-adjusted proxies. MH and cancer screening ROI are below 2:1, reflecting limitations of cited evidence. All figures ±30–50% uncertainty - directional planning estimates only, not audited projections. Use sliders to model different reach scenarios.
Population base: 64,565 total / ~52,297 adults · Primary burden: 15,430 DALYs (frontier LE + MH remission-adj; 95% UI 14,459–16,481) · Planning sensitivity (MI LE 78.6 yrs): 10,579 DALYs · Monte Carlo n=10,000 · Full methods →
Investment vs. Savings by Intervention
$ millions/year at current reach settings
ROI Ratio by Intervention
$ saved per $1 invested · error bars show literature range
ROI Summary Table
All interventions · 5-year cumulative · Current reach settings
Intervention
Target pop.
Reach
Patients
Investment/yr
Savings/yr
ROI ratio
Net benefit/yr
Relative impact
💡 Grant Application Framing
How to use this ROI analysis in funding applications